|
Total [10, 21, 22]
|
|
Number of patients
|
n = 126
|
|
Mean age, years
|
Mean age = 16.44 ± 0.6 years
|
|
Females, n (%)
|
76 (60%)
|
|
Four categories
|
Pigmentary changes only (n = 79), neurofibromas only (n = 14), pigmentary changes and neurofibromas (n = 15), plexiform neurofibromas only (n = 18)
|
|
NF1-associated complications
|
language delay (n = 1), learning disability (n = 7), ADHD (n = 3), skeletal abnormalities [11] and intracranial vasculopathy (n = 1)
|
|
Lara-Corrales et al. [21]
|
|
Number of patients
|
n = 60
|
|
Recruited from
|
Hospital for Sick Children, Toronto, Canada, in 1992–2012
|
|
Mean age, years
|
Mean age = 10.6 ± 4.6 years
|
|
Females, n (%)
|
32 (53%)
|
|
Four categories
|
Pigmentary changes only (n = 39), neurofibromas only (n = 9), pigmentary changes and neurofibromas (n = 2), plexiform neurofibromas only (n = 10)
|
|
NF1-associated complications
|
Learning disability (n = 7), bony changes (n = 6), seizures (n = 1)
|
|
Tanito et al. [10]
|
|
Number of patients
|
n = 58
|
|
Recruited from
|
The Jikei University Hospital, in 2004–2007, and at the Jikei University Daisan Hospital, in 2007–2011
|
|
Mean age, years
|
Mean age = 23.4 [1;69] years
|
|
Females, n (%)
|
42 (72%)
|
|
Four categories
|
Pigmentary changes only (n = 32), neurofibromas only (n = 5), pigmentary changes and neurofibromas (n = 13), plexiform neurofibromas only (n = 8)
|
|
NF1-associated complications
|
Bone deformity (n = 3), language delay (n = 1)
|
|
Marwaha et al. [22]
|
|
Number of patients
|
n = 8
|
|
Recruited from
|
Hospital for Sick Children, Toronto, Canada. Years unknown
|
|
Mean age, years
|
Mean age = 9.8 [1;16] years
|
|
Females, n (%)
|
2 (25%)
|
|
Four categories
|
Pigmentary changes only (n = 7), neurofibromas only (n = 0), pigmentary changes and neurofibromas (n = 1), plexiform neurofibromas only (n = 0)
|
|
NF1-associated complications
|
Sphenoid wing dysplasia (n = 1), intracranial vasculopathy (n = 1), tibial rotation (n = 1), ADHD (n = 3)
|
